Ethacrynic Acid Ototoxicity, Potentiation by Kanamycin

Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆

In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity. To this end, healthy BALB/c mice were injected subcutaneously with alpha-lipoic acid and kanamycin for 14 days. Auditory brainstem response test showed that inc...

Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant.

S-2 (3-aminopropylamino)ethylphosphorothioate ameliorates hearing losses due to ototoxic doses of kanamycin sulfate in the guinea pig when administered one hour before the antibiotic. Since this radioprotectant is believed to operate as a free-radical scavenger, kanamycin ototoxicity may involve free radicals.

Hepatocellular damage with ethacrynic acid.

A man aged 25 with rheumatic heart disease (mitral stenosis and aortic stenosis with incompetence), subacute bacterial endocarditis, and gross congestive cardiac failure was admitted to the K.E.M. Hospital, Bombay, on 24 August 1966. He was given the appropriate antibiotic therapy, a low-salt diet, digitalis, and ethacrynic acid. In the first eight days the diuretic response was good and he los...

Hypotensive Effect of Ethacrynic Acid.

THE benzothiadiazine derivatives were the first diuretic compounds that could safely be administered over considerable periods of time and yet retain their effectiveness. In the course of the investigation of their diuretic properties in man it became apparent that they also possessed weak antihypertensive properties.' The mechanism of this action remains uncertain, and there is doubt as to whe...

درباره اثر مدر اسید اتاکرینیک ETHACRYNIC ACID